The Cybercyte Plug and Play Dynamic Clamp

The Cybercyte electronically expresses currents in cells being examined
using voltage clamp, and can be used for a variety of research
purposes. We provide custom installation, custom modelling and
analysis, and can customize the Cybercyte for your specific applications.

The Cybercyte is a simple plug and play dynamic clamp system, which
works with your existing voltage clamp system. The user interface is
driven by icons, making it easy to switch between electronically
expressed currents in real time.

iPSCD Cardiac Myocytes
The Cybercyte electronically expresses IK1 in induced pluripotent stem
cell derived cardiac myocytes. This restores the resting potential,
resets ion channels, and the cells have normal Action Potential
morphology. Cells can clearly be identified as atrial or ventricular, which
enables focused experiments on one cell type only.

Other Cell Types
The Cybercyte can be used to eliminate or add currents in any cell
type. An example of this is found in the paper by
Cordiero et al.  We
are happy to work with you on your custom projects.
Call Us Toll Free at: 1-855-351-6285
The original publication which describes the Cybercyte:
Electronic "expression" of the inward rectifier in cardiocytes derived from
human-induced pluripotent stem cells  Bett GC. Kaplan AD, Lis A, Cimato TR,
Tzanakakis ES, Zhou Q, MOrales MJ, Rasmusson RL
Heart Rhythm 2013 Dec
Other publications using the Cybercyte:
Reconciling Computer Models and Stem Cell Models of Human Cardiac
Repolarization Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A,
Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L.
Research 2015 106(1):6-7
Mechanism of automaticity in cardiomyocytes derived from human induced
pluripotent stem cells Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC,
Rasmusson RL, London B, Salama G.
Journal of Molecular and Cellular Cardiology
2015 81:81-93
Regional Variation of the inwardly rectifying potassium current in the canine
heart and the contributions to differences in action potential repolarization
Cordiero JM, Zeina T, Goodrow R, Kaplan AD, Thomas LM, Nesterenko VV, Treat
JA, Hawel L, Byus C, Bett GC, Rasmusson RL, Panama BK.
Journal of Molecular
and Cellular Cardiology 2015 in press
Plug and Play Dynamic Clamp
only $4,750
The SC1 Dynamic Clamp System from Cytocybernetics
offers affordable, high performance, plug and play dynamic
clamp. The SC1 is user friendly, simple to use, fully
upgradable, and available for a limited time for
only $4,750!

Think of all the experiments that are now within your reach
when you use the affordable and reliable SC1 Dynamic
Clamp System from Cytocybernetics!