Cytocybernetics: Rapid and Reliable HERG Screening

The HERG Assay
HERG channel assay provides information on the ability of a compound to block the
HERG channel, which is the alpha subunit underlying the delayed repolarization
current, IKr.
Screening Services

HERG Quick Check:
This assay is for simple early stage feedback. Compounds are tested against
against HERG1A. Data is obtained for two compound  concentrations in two cells.


Advanced HERG Assays:
This is an in depth assay, with a full range of compound concentrations. Depending
on Customer requirements, the report can include dose-reposonse relationship, use
dependence, models of HERG block.

Call Cytocybernetics To discuss your specific requirements, at 1-855-351-6285, or
email us at
quotes@cytocybernetics.com.
Cytocybernetics: Connecting Cells and Computers
Cybernetics, your best choice for HERG Screening

The Team at Cytocybernetics has been working with the HERG channel since it was
first identified.
A Sample of HERG Publications from the Team at Cytocybernetics

A quantitative analysis of the activation and in activation kinetics of HERG expressed
in Xenopus oocytes Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. J.
Physiol, 1997, 502: 45-60.

Modulation of HERG affinity for E-4031 by K+ and C-type inactivation Wang S,
Morales MJ, Liu S, Strauss HC, Rasmusson RL. FEBS Letters, 1997, 417: 43-7.

Functionally-distinct proton binding in HERG suggests the presence of two binding
sites Bett GC, Rasmusson RL. Cell Biochem Biophys 2003, 39: 183-93.

Regulation of the voltage-insensitive step of HERG activation by extracellular pH
Zhou Q, Bett GC. 2010, 298: H1710-8

Models of HERG gating Bett GC, Zhou QC, Rasmusson RL. Biopys J 2011, 101:
631-42