Cytocybernetics: Rapid and Reliable HERG Screening
The HERG Assay
HERG channel assay provides information on the ability of a compound to block the
HERG channel, which is the alpha subunit underlying the delayed repolarization
HERG Quick Check:
This assay is for simple early stage feedback. Compounds are tested against
against HERG1A. Data is obtained for two compound concentrations in two cells.
Advanced HERG Assays:
This is an in depth assay, with a full range of compound concentrations. Depending
on Customer requirements, the report can include dose-reposonse relationship, use
dependence, models of HERG block.
Call Cytocybernetics To discuss your specific requirements, at 1-855-351-6285, or
email us at firstname.lastname@example.org.
Cybernetics, your best choice for HERG Screening
The Team at Cytocybernetics has been working with the HERG channel since it was
A Sample of HERG Publications from the Team at Cytocybernetics
A quantitative analysis of the activation and in activation kinetics of HERG expressed
in Xenopus oocytes Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. J.
Physiol, 1997, 502: 45-60.
Modulation of HERG affinity for E-4031 by K+ and C-type inactivation Wang S,
Morales MJ, Liu S, Strauss HC, Rasmusson RL. FEBS Letters, 1997, 417: 43-7.
Functionally-distinct proton binding in HERG suggests the presence of two binding
sites Bett GC, Rasmusson RL. Cell Biochem Biophys 2003, 39: 183-93.
Regulation of the voltage-insensitive step of HERG activation by extracellular pH
Zhou Q, Bett GC. 2010, 298: H1710-8
Models of HERG gating Bett GC, Zhou QC, Rasmusson RL. Biopys J 2011, 101: