Cytocybernetics is the sole supplier of the patented CytoVolt1 (Di- 4ANBDQBS, JPW-6033), an independently validated, long lasting, non-toxic, near infra-red, voltage sensitive dye. Features include:
• No Dye Toxicity • No Phototoxicity • High ΔF/F: 15-20% • High Quantum Yield • High Linearity • Fast Response Time • Independently Validated • Compatible with Optogenetics
CytoVolt1 (Di-4-ANBDQBS, JPW6033) lasts 8 times longer than the leading competitor, Di-4-ANEPPS. It can be excited with red light (615-650nm) which does not damage cells thus eliminating phototoxic effects. It is highly linear over the physiological range and, due to the mechanism of molecular stark effect, has very fast response times, below a microsecond. In addition, the slow rate of internalization allows time for voltage calibration, and the high ΔF/F offers superior signal-to-noise ratio.
The Technical Specifications of CytoVolt1 are available here, along with a list of papers using this powerful dye.